Physicochemical and Biological Characterization of Composites in Hydrogel State made of Collagen, Guar gum and Calcium/Aminoacid based MOFs

Calcium/aminoacids based MOFs (CaHis, CaPhe, and CaTrp) were synthesized by the hydrothermal method. Then, these materials applied as a filler in synthesis of composites hydrogel state on biopolymer matrix collagen -guar gum (CG). The calcium characterized ATR-FTIR XRD, while morphology, degradation profile, crosslinking swelling degree, proliferation cell viability porcine dermis fibroblasts characteristics analyzed for i n state. results indicated that incorporation Ca-MOFs into CG enhances physicochemical properties CG, but without affecting their biocompatibility. In this way, CG-CaTrp demonstrated to be material with best biological potential application tissue engineering skin.